Preparation of S-(N6,N6-dimethyladenosyl)-l-methionine
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چکیده
منابع مشابه
Tumor uptake studies of S-adenosyl-L-[methyl-11C]methionine and L-[methyl-11C]methionine.
Tumor accumulation of S-adenosyl-L-[methyl-11C]methionine ([11C]SAM) was investigated in mice bearing mammary carcinoma (FM3A) and in rats bearing ascitic hepatoma (AH109A). After injection of [11C]SAM the blood clearance of 11C radioactivity was rapid. The 11C level was relatively high in both tumors. The uptake ratios of tumor to organ increased with time in several organs, especially in brai...
متن کاملPreparation of d- and l-methionine from dl-methionine by enzymatic resolution.
It has been shown previously (1,2) that the synthesis of CO-NH linkages by papain as well as by other proteinases is characterized by extreme stereochemical specificity. Thus, upon the addition of cysteine-activated papain to a mixture of carbobenzoxy-nn-glutamic acid and aniline, there is formed carbobenzoxy-L-glutamic acid anilide, which separates in crystalline form. The carbobenzoxy-n-gluta...
متن کاملPurification of rat liver S-adenosyl-L-methionine decarboxylase.
The amount of S-adenosyl-l-methionine decarboxylase present in rat liver was enhanced 17-fold by administration of methylglyoxal bis(guanylhydrazone),* a specific inhibitor of the enzyme. The enzyme was purified 1400-fold in 50% yield from such liver extracts by chromatography on columns of the inhibitor bound to Sepharose. The purified enzyme had no spermidine synthetase activity.
متن کاملThe enzymatic decomposition of S-adenosyl-L-methionine.
The role of S-adenosyl-n-methionine as a methyl donor has been investigated in mammalian systems (1) and in microbial metabolism (2-4). In addition, the compound is involved in the formation of spermidine from putrescine (5). Information concerning the stability of S-adenosylmethionine in various enzymatic systems is a necessary prerequisite for studies concerning its role in group transfer. In...
متن کاملS-Inosyl-L-Homocysteine Hydrolase, a Novel Enzyme Involved in S-Adenosyl-L-Methionine Recycling.
UNLABELLED S-Adenosyl-L-homocysteine, the product of S-adenosyl-L-methionine (SAM) methyltransferases, is known to be a strong feedback inhibitor of these enzymes. A hydrolase specific for S-adenosyl-L-homocysteine produces L-homocysteine, which is remethylated to methionine and can be used to regenerate SAM. Here, we show that the annotated S-adenosyl-L-homocysteine hydrolase in Methanocaldoco...
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ژورنال
عنوان ژورنال: Carbohydrate Research
سال: 1985
ISSN: 0008-6215
DOI: 10.1016/s0008-6215(00)90739-0